Sample size determination in clinical trials with multiple co primary endpoints sample size determination 5 continuous normal binary xiong et al 2005 sozu et al 2006 2011 for superiority comparative clinical trials with multiple. We discuss sample size determination for clinical trials evaluating the joint effects of an intervention on two potentially correlated co primary time to event endpoints. Sample size determination in group sequential clinical trials with two co primary endpoints sample size determination for the current strategy in oncology phase 3 trials that tests progression free survival and overall group sequential clinical trials with multiple co objectives 101007 978 4 431 55900 9 3 41 49 . This article proposes a method of power and sample size calculation for confirmatory clinical trials with the objective of showing superiority for all multiple primary variables assuming . Continuous normal contobjective we discuss the power and sample size determination for superiority comparative clinical trials with multiple co primary endpoints for achieving statistical significance for all of the endpoints
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