Advances in the immunopathogenesis of multiple sclerosis yadav sk1 mindur je ito k dhib jalbut s author information 1department of neurology rutgers robert wood johnson medical school piscataway new jersey 08854 usa. Summary a better understanding of immune mediated mechanisms in the pathogenesis of multiple sclerosis and the contribution of environmental risk factors toward the development of multiple sclerosis will help further improve therapeutic approaches to prevent disease progression. Immunopathogenesis in the early i and progressive ii stages of multiple sclerosis schematic diagram represents current understanding of the immunopathogenesis of multiple sclerosis. Therefore b cells cd8 t cells and microglia macrophages can also play an important role in the immunopathogenesis of multiple sclerosis apart from proinflammatory cd4 th1 th17 cell subsets furthermore increasing evidence indicates that environmental risk factors such as vitamin d deficiency epstein barr virus smoking western diet . 1 the affinity spectrum of myelin basic protein reactive t cells 2 the naive and memory mbp reactive cd4 t cell repertoire implications for the autoimmune concept in multiple sclerosis 3 from specificity to degeneracy to molecular mimicry antigen recognition of human autoreactive and pathogen specific cd4 t cells 4 immune
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