Vol 7 antibody expression and production edited by mohamed al rubeai university college dublin ireland 123 editor prof mohamed al rubeai school of chemical and bioprocess m al rubeai ed antibody expression and production cell engineering 7 1 doi 101007 978 94 007 1257 7 1 c springer science business media bv 2011. After expression recombinant antibodies are usually isolated from the periplasmic fraction antibody expression and production cell engineering netherlands springer 2011 p 1 24 162 girod p a mermod n use of scaffold matrix attachment regions for protein production. Monoclonal antibody production by recombinant expression technology has been a major breakthrough in the therapeutic antibody development context as it leads to several advantages over the traditional antibody production method from hybridoma reproducibility control and security monoclonal antibody production for therapeutic applications requires high control and reproducibility. Our antibody engineering and expression service center will fill the gap of the much needed expertise for advancement of monoclonal antibodies from early discovery to lead optimization and preclinical development for the research and drug discovery communities. Host cell lines for mab production and host cell engineering the most prominent host cell lines for recombinant mab expression are cho ns0 sp2 0 hek293 and perc6 however most literature is available for cho cells which are still the workhorse for 70 of todays industrially produced protein therapeutics jayapal et al 2007
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