Drug hypersensitivity is an immune mediated reaction to a drug symptoms range from mild to severe and include rash anaphylaxis and serum sickness diagnosis is clinical skin testing is occasionally useful treatment is drug discontinuation supportive treatment eg with antihistamines and sometimes desensitization. As drug hypersensitivity syndrome can occur up to eight weeks after first exposure to the responsible drug a great degree of care is required when determining the responsible medicine a temporal association between medicine use and the start of the syndrome is the strongest evidence. Drug hypersensitivity drug reactions can be classified according to whether they occur as a result of the mode of action on target or in some other way off target fig 48316 type a on target reactions account for over 80 of drug reactions. Drug hypersensitivity reactions are unpredictable adverse drug reactions they manifest either within 1 6 h following drug intake immediate reactions with mild to life threatening symptoms of anaphylaxis or several hours to days later delayed reactions primarily as exanthematous eruptions. Drug hypersensitivity reactions dhr include allergic exaggerated pharmacologic and pseudoallergic reactions to medications that result from an enhanced immunologic or inflammatory response the classification and clinical features of drug hypersensitivity will be reviewed here beginning with a
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