Fibrocytes have been shown to promote angiogenesis which is a requisite for the development and maintenance of new granulation tissue allowing wound closure and restoration of tissue integrity cultured fibrocytes participate in all aspects of neovascularization. Furthermore regulatory pathways involving serum amyloid p leukocyte specific protein 1 and adenosine a2a receptors have emphasized the significant role that fibrocytes have in wound healing and fibrosis the therapeutic targeting of fibrocytes holds promise for the augmentation of wound repair and the treatment of different fibrosing disorders. Fibrocytes in health and disease author links open overlay panel erica l herzog a richard bucala b fibrocytes in lung disease fibrotic lung disease can affect the airway asthma and the parenchyma pulmonary fibrosis chronic kidney disease is a major public health burden that results from a variety of acute or chronic conditions. As in other organ specific fibroses the contribution of fibrocytes to kidney repair and remodeling is an ongoing field of investigation chronic kidney disease is a major public health burden that results from a variety of acute or chronic conditions. Fibrocytes could participate in the pathogenesis of scleroderma lung disease through any or all of these functions and may be useful biomarkers of disease activity
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