The hla region and autoimmune disease associations and mechanisms of action scl gough and mj simmonds the hla region encodes several molecules that play key roles in the immune system strong association between the hla region and autoimmune disease aid has been established for over fifty years hla class i disease mechanisms. Welcome to hla disease associations the autoimmune diseases site the association between genetics particularly the genes of the major histocompatibility complex mhc and many autoimmune diseases has long been known even though the actual disease susceptibility genes or the mechanism that confers the disease often remain to be elucidated. Antibodies against disease associated hla haplotypes have been proposed as a treatment for severe autoimmune diseases 28 donor specific hla antibodies have been found to be associated with graft failure in renal heart lung and liver transplantation. The hla system has an important role in disease susceptibility and resistance especially in autoimmune diseases and cancer this study is the first report about hla genetic variability and . The association between the human major histocompatibility complex mhc hla human leukocyte antigen b27 and its spectrum of hla b27 associated inflammatory diseases and acute anterior uveitis was originally described in 1973 and remains one of the strongest hla disease associations brewerton et al 1973a c b schlosstein et al 1973
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