Neurogenic inflammation is mediated by the release of the neuropeptides calcitonin gene related peptide cgrp and substance p sp from nociceptors which act directly on vascular endothelial and smooth muscle cells 2 5. Inflammation of neurological tissue caused by the release of inflammatory mediators or afferent neurons is classified as neurogenic inflammation usually the inflammation in various body tissues is caused by the bodys immune response to a perceived infection or risk of infection. Neurogenic inflammation neurogenic inflammation is a major cause of acute inflammation in many tissue types as well as a primary mechanism of lung injury for a number of chemical agents and sensory irritants. Neurogenic inflammation ni is the physiological process by which mediators are released directly from the cutaneous nerves to initiate an inflammatory reaction this results in production of local inflammatory responses including erythema swelling temperature increase tenderness and pain12345
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