The concept of gene therapy seems straightforward but this is clearly an oversimplification and numerous problems and risks exist that prevent gene therapy using viral vectors viruses can usually infect more than one type of cell. How does gene therapy work certain viruses are often used as vectors because they can deliver the new gene by infecting the cell the viruses are modified so they cant cause disease when used in people the genetic science learning center at the university of utah provides information about various technical aspects of gene . The panel recommended that investigators return to the laboratory and focus on the basic science underlying gene therapy approaches development of new vectors and a better understanding of target cells sparked a second generation of clinical trials in the late 1990s and early 2000s. Viral gene therapy strategies from basic science to clinical application young ls1 searle pf onion d mautner v paramount is the safety of these virus vectors and a greater understanding of the virus host interaction is key to optimizing the use of these vectors for routine clinical use recent developments in the modification of the
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